(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

Base Information

Chemical Name:(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide
CAS No.:1347757-29-2
Molecular Formula:C₂₆H₂₉N₅O₃
Molecular Weight:459.548
Hs Code.:

Synonyms:(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

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Chemical Property of (S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

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Technology Process of (S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

There total 5 articles about (S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1347758-09-1
(S)-1-(2-chloropyrimidin-4-yl)-N-(4-methylbenzyl)piperidine-3-carboxamide

: 22013-33-8
6-amino-3,4-benzodioxane

: 1347757-29-2
(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

Guidance literature:: In dimethyl sulfoxide; at 20 - 90 ℃; for 16h;

Reference yield:

: 1359818-64-6
C₁₄H₂₀N₂O

: 1347757-29-2
(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 20 h / 22 - 23 °C / Inert atmosphere

2: dimethyl sulfoxide / 16 h / 90 °C / Inert atmosphere

With triethylamine; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm201565s

Reference yield:

: 1347758-08-0
(S)-tert-butyl 3-(4-methylbenzylcarbamoyl)piperidine-1-carboxylate

: 1347757-29-2
(S)-1-(2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-4-pyrimidinyl)-N-(4-methylbenzyl)-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / diethyl ether; dichloromethane / 20 h / 22 - 23 °C / Inert atmosphere

2: triethylamine / ethanol / 20 h / 22 - 23 °C / Inert atmosphere

3: dimethyl sulfoxide / 16 h / 90 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm201565s