2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester

Base Information

• Chemical Name: 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester
• CAS No.: 917496-24-3
• Molecular Formula: C₂₆H₂₁Cl₂FN₄O₄
• Molecular Weight: 543.382

Synonyms:2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester

Chemical Property of 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester

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Technology Process of 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester

There total 2 articles about 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl 2-ethoxymethylenemalonate (87-13-8) + 4-amino-7-(3-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine (243665-92-1) → 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester (917496-24-3)

Guidance literature:

In diphenylether; at 130 - 140 ℃; for 4h;

DOI:10.1002/jhet.5570430530

Reference yield:

2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile (243665-86-3) → 2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester (917496-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide

2: 75 percent / diphenyl ether / 4 h / 130 - 140 °C

In diphenylether; N,N-dimethyl-formamide; 2: Gould-Jacob reaction;

DOI:10.1002/jhet.5570430530

Reference yield:

2-{[7-(3-chloro-4-fluoro-phenyl)-5-(4-chloro-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-methylene}-malonic acid diethyl ester (917496-24-3) → 3-(3-chloro-4-fluoro-phenyl)-1-(4-chloro-phenyl)-6-oxo-3,6-dihydro-3,4,5a,9-tetraaza-cyclopenta[a]naphthalene-7-carboxylic acid ethyl ester

Guidance literature:

In diphenylether; at 250 ℃; for 1h;

DOI:10.1002/jhet.5570430530

upstream raw materials:

diethyl 2-ethoxymethylenemalonate

4-amino-7-(3-chloro-4-fluorophenyl)-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidine

2-amino-1-(3-chloro-4-fluoro-phenyl)-4-(4-chloro-phenyl)-1H-pyrrole-3-carbonitrile

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