(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

Base Information

Chemical Name:(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine
CAS No.:1321963-70-5
Molecular Formula:C₁₄H₁₂BrF₃N₄O₄
Molecular Weight:437.173
Hs Code.:

Synonyms:(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

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Chemical Property of (S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

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Technology Process of (S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

There total 3 articles about (S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 187235-66-1
(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine

: 1114808-87-5
2-bromo-4-(trifluoromethoxy)benzaldehyde

: 1321963-70-5
(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

Guidance literature:: (S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine; 2-bromo-4-(trifluoromethoxy)benzaldehyde; With acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With sodium cyanoborohydride; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jm1010644

Reference yield:

: 883546-30-3
2-bromo-1-iodo-4-(trifluoromethoxy)benzene

: 1321963-70-5
(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 0.5 h / Inert atmosphere

1.2: 16 h / 95 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C

3.1: acetic acid / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 24 h

With sodium periodate; osmium(VIII) oxide; acetic acid; triethylamine; In water; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm1010644

Reference yield:

: 1321963-17-0
(E)-2-bromo-1-styryl-4-(trifluoromethoxy)benzene

: 1321963-70-5
(S)-N-(2-bromo-4-(trifluoromethoxy)benzyl)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium periodate; osmium(VIII) oxide / water; acetone; tert-butyl alcohol / 16 h / 0 - 20 °C

2.1: acetic acid / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 24 h

With sodium periodate; osmium(VIII) oxide; acetic acid; In water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jm1010644