1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

Base Information

Chemical Name:1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea
CAS No.:932037-00-8
Molecular Formula:C₂₀H₃₁F₃N₂O₂
Molecular Weight:388.474
Hs Code.:

Synonyms:1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

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Technology Process of 1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

There total 5 articles about 1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1,1-diisobutyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

: 106-94-5
propyl bromide

: 932037-00-8
1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

: 1,1-diisobutyl-3-[4-(2,2,2-trifluoro-1-propoxy-ethyl)-phenyl]-urea

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

: 932036-95-8
1,1-diisobutyl-3-(4-trifluoroacetyl-phenyl)-urea

: 932037-00-8
1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: NaH / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2006.09.023

Reference yield:

: 619-50-1
4-nitrobenzoic acid methyl ester

: 932037-00-8
1,1-diisobutyl-3-propyl-3-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: TBAF / CH₂Cl₂ / -78 - 20 °C

1.2: 92 percent / aq. HCl / acetone

2.1: 79 percent / Fe; AcOH / ethanol / Heating

3.1: diethylamine / CH₂Cl₂ / 20 °C

4.1: NaBH₄ / methanol

5.1: NaH / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; iron; sodium hydride; acetic acid; diethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.09.023