(2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

Base Information

Chemical Name:(2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid
CAS No.:105119-26-4
Molecular Formula:C₁₈H₂₄O₅
Molecular Weight:320.386
Hs Code.:

Synonyms:(2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

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Chemical Property of (2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

Chemical Property:

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Technology Process of (2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

There total 16 articles about (2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 931-94-2
1,1-dimethoxycyclopentane

: 122237-37-0
(2R,3R)-2-(Benzyloxymethyl)-2,3-dihydroxypentanoic Acid

: 105119-26-4
(2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

Guidance literature:: With toluene-4-sulfonic acid; In various solvent(s); at 20 ℃; for 4h;

Reference yield: 12.0%

: (R)-2-Benzyloxymethyl-3-ethyl-1,4-dioxa-spiro[4.4]nonane-2-carboxylic acid methyl ester

: 105065-63-2
(2S,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

: 105119-26-4
(2R,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

Guidance literature:: With hydroxide;

Reference yield:

: 931-94-2
1,1-dimethoxycyclopentane

: 105065-63-2,105119-26-4
(2RS,3R)-2-(Benzyloxymethyl)-3-ethyl-1,4-dioxaspiro<4.4>nonane-2-carboxylic Acid

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / p-toluenesulfonic acid / various solvent(s) / 3 h

2: 58 percent / pyridine / 1) 4 h, -20 deg C, 2) 12 h, -15 deg C

3: 84 percent / 80percent sodium hydride in paraffin oil / tetrahydrofuran / 1) 1 h, 0 deg C, 2) 4 h, 20 deg C

4: 94 percent / sodium iodide, sodium acetate, aq. acetic acid, zinc dust / 2 h / 0 °C

5: 87 percent / H₂ / 5percent Pt on carbon / methyl acetate / 10 h

6: 1.) n-BuLi, N,N-diisopropylamine / 1.) THF, hexane, 0 deg C, then -78 deg C, 30 min, 2.) -78 deg C, 30 min

7: 2M KOH / methanol; H₂O / 4 h / Heating

With potassium hydroxide; n-butyllithium; hydrogen; sodium acetate; sodium hydride; toluene-4-sulfonic acid; acetic acid; diisopropylamine; sodium iodide; zinc; platinum on activated charcoal; In tetrahydrofuran; pyridine; methanol; acetic acid methyl ester; water;