1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride

Base Information

• Chemical Name: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride
• CAS No.: 56243-25-5
• Molecular Formula: C19H20N2
• Molecular Weight: 276.381
• Hs Code.: 2933399090
• Mol file: 56243-25-5.mol

Synonyms:1-benzyl-4-phenylpiperidine-4-carbonitrile

Chemical Property of 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride

Chemical Property:

• Vapor Pressure: 1.3E-07mmHg at 25°C
• Melting Point: 250-259oC
• Boiling Point: 430.4oC at 760mmHg
• Flash Point: 184.3oC
• PSA: 27.03000
• Density: 1.12g/cm3
• LogP: 4.48388

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-4-cyano-4-phenylpiperidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R20/21/22:吸入、皮肤接触和不慎吞咽有害
• Hazard Codes: Xn:有害物质‖Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A piperidine derivative as calcium channel blockers

Technology Process of 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride

There total 13 articles about 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C14H19NO6S2 + benzylamine (100-46-9) → 1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 120 ℃; for 12h; Sealed tube;

Reference yield: 87.0%

N,N-bis(2-chloro-ethyl)-benzenemethanamine (55-51-6) + phenylacetonitrile (140-29-4) → 1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5)

Guidance literature:

With sodium hydroxide; cetyltributylphosphonium bromide; In water; at 100 ℃; for 1h;

Reference yield: 54.0%

oxirane (75-21-8,99932-75-9) + phenylacetonitrile (140-29-4) + benzylamine (100-46-9) → 1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5)

Guidance literature:

phenylacetonitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -30 ℃; for 0.5h; Inert atmosphere;

oxirane; In tetrahydrofuran; for 0.5h; Inert atmosphere;

benzylamine; Further stages;

upstream raw materials:

N,N-bis(2-chloro-ethyl)-benzenemethanamine

phenylacetonitrile

1,5-dichloro-3-cyano-3-phenylpentane

benzylamine

Downstream raw materials:

1-benzyl-4-phenyl-piperidine-4-carbaldehyde

(4-phenylpiperidin-4-yl)methanamine

(4-phenyl-[4]piperidylmethyl)-urea

1-(1-benzyl-4-phenyl-[4]piperidyl)-ethanone