1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Base Information

Chemical Name:1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene
CAS No.:201232-77-1
Molecular Formula:C₂₆H₄₆O₅Si₂
Molecular Weight:494.819
Hs Code.:

Synonyms:1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Suppliers and Price of 1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

There total 4 articles about 1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (4-(methoxymethoxy)phenyl)magnesium bromide

: 201232-73-7
p-tert-butylphenyl 4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

: 201232-77-1
1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Guidance literature:: With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; at -40 ℃; for 2h;
DOI:10.1021/jo9714674

Reference yield: 80.0%

: 25458-45-1
p-methoxymethoxybromobenzene

: 201232-73-7
p-tert-butylphenyl 4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

: 201232-77-1
1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Guidance literature:: p-methoxymethoxybromobenzene; With magnesium; In tetrahydrofuran;

p-tert-butylphenyl 4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside; With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; at -40 ℃; for 24h;
DOI:10.1081/CAR-120026468

Reference yield:

: 171082-23-8
4-t-butylphenyl4, 6-di-O-acetyl-2,3-dideoxy-α-D-erythro-hex-2-enopyranoside

: 201232-77-1
1-[4,6-di-O-tert-butyl(dimethyl)silyl-2,3-dideoxy-β-D-erythro-hex-2-enopyranosyl]-4-(methoxymethoxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: CH₃ONa / methanol / 1 h / 25 °C

2: imidazole / dimethylformamide / 48 h / Ambient temperature

3: 80 percent / NiCl₂(dppe) / tetrahydrofuran / 2 h / -40 °C

With 1H-imidazole; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo9714674