3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Base Information

Chemical Name:3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole
CAS No.:1354699-98-1
Molecular Formula:C₄₃H₄₈ClFN₃O₆P
Molecular Weight:788.296
Hs Code.:

Synonyms:3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Suppliers and Price of 3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

There total 4 articles about 3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1354699-97-0
3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-4-fluoroindole

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1354699-98-1
3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/ja208510m

Reference yield:

: 1354699-95-8
3-chloro-4-fluoroindole

: 1354699-98-1
3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / acetonitrile / 0.33 h / 20 °C

1.2: 4 h / 20 °C

2.1: sodium methylate / tetrahydrofuran; ethanol / 3 h / 20 °C

3.1: pyridine / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

With pyridine; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/ja208510m

Reference yield:

: 387-43-9
4-fluoroindole

: 1354699-98-1
3-chloro-1-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropyl-β-cyanoethylphosphoramidyl)-β-D-ribofuranosyl]-4-fluoroindole

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / dichloromethane / 3 h / 20 °C

2.1: sodium hydride / acetonitrile / 0.33 h / 20 °C

2.2: 4 h / 20 °C

3.1: sodium methylate / tetrahydrofuran; ethanol / 3 h / 20 °C

4.1: pyridine / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 20 °C

With pyridine; N-chloro-succinimide; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/ja208510m