(3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

Base Information

Chemical Name:(3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)
CAS No.:123486-75-9
Molecular Formula:C₁₉H₁₉F₃N₂O₅
Molecular Weight:412.365
Hs Code.:

Synonyms:(3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

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Chemical Property of (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

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Technology Process of (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

There total 12 articles about (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 123486-69-1,123538-37-4,123538-38-5
diethyl (3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifuoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylate

: 123486-75-9
(3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 2h;
DOI:10.1021/jo00284a036

Reference yield:

: 123486-71-5,123538-36-3
5-ethyl 3-<5-methyl-2-(1-methylethyl)cyclohexyl> 3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylate

: 123486-75-9
(3aS,4S,7aR)-6,7a-Dimethyl-4-(2-trifluoromethyl-phenyl)-3a,4,7,7a-tetrahydro-isoxazolo[5,4-b]pyridine-3,5-dicarboxylic acid 5-ethyl ester

Guidance literature:: With Claisen's alkali; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1021/jo00284a036

Reference yield:

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 123486-75-9
(3aα,4α,7aα)-3a,4,7,7a-tetrahydro-6,7a-dimethyl-4-<2-(trifluoromethyl)phenyl>isoxazolo<5,4-b>pyridine-3,5-dicarboxylic acid 5-(ethyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / 10percent aq. NaOH / Ambient temperature

2: 38 percent / ethanol / 24 h / 170 °C

3: 74 percent / Et₃N / diethyl ether / 12 h

4: 97 percent / 1 N NaOH / tetrahydrofuran / 2 h

With sodium hydroxide; triethylamine; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jo00284a036