1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone

Base Information

• Chemical Name: 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone
• CAS No.: 712277-78-6
• Molecular Formula: C₂₀H₁₈O₂Si
• Molecular Weight: 318.447

Synonyms:1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone

Chemical Property of 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone

There total 3 articles about 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{2-[1-hydroxy-3-(trimethylsilyl)-2-propynyl]-phenylethynyl}-phenyl → 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone (712277-78-6)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0498213

Reference yield:

4-ethynylphenol (2200-91-1) → 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone (712277-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 20 °C

2: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/jo0498213

Reference yield:

1-(2-iodophenyl)-3-(trimethylsilyl)prop-2-yn-1-ol → 1-{2-[2-(1-hydroxyphenyl)-1-ethynyl]phenyl}-3-(trimethylsilyl)propynone (712277-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CuI; Et₃N / PdCl₂(PPh₃)2 / tetrahydrofuran / 20 °C

2: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; 1: Sonogashira coupling;

DOI:10.1021/jo0498213

upstream raw materials:

4-ethynylphenol

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