3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride

Base Information

• Chemical Name: 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride
• CAS No.: 868964-18-5
• Molecular Formula: C₁₃H₁₃BrClNO₄S
• Molecular Weight: 394.674

Synonyms:3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride

Chemical Property of 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride

Chemical Property:

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Technology Process of 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride

There total 1 articles about 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-N-acetylindoline (22190-38-1) → 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride (868964-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 63 percent / ClSO₃H / 3 h / 65 - 70 °C

2.1: aq. Na₂SO₃; NaHCO₃ / 0.5 h / 90 °C / pH 9 - 10

2.2: aq. AcOH / 20 °C

3.1: H₂O / 20 °C

4.1: PCl₅ / toluene / Heating

With chlorosulfonic acid; phosphorus pentachloride; sodium hydrogencarbonate; sodium sulfite; In water; toluene;

DOI:10.1055/s-2004-834888

Reference yield:

4-diethylamino-o-toluidine (148-71-0) + 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride (868964-18-5) → 3-(1-acetyl-5-bromo-2,3-dihydro-1H-indole-7-sulfonyl)-N-(4-diethylamino-2-methyl-phenyl)-propionamide

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 55 ℃; for 1h;

DOI:10.1055/s-2004-834888

Reference yield:

2-(3,4-diethoxyphenyl)ethylamine (61381-04-2) + 3-[(1-acetyl-5-bromo-2,3-dihydro-1H-indol-5-yl)sulfonyl]propanoic acid chloride (868964-18-5) → 3-(1-acetyl-5-bromo-2,3-dihydro-1H-indole-7-sulfonyl)-N-[2-(3,4-diethoxy-phenyl)-ethyl]-propionamide

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 55 ℃; for 1h;

DOI:10.1055/s-2004-834888

upstream raw materials:

5-bromo-N-acetylindoline

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