3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

Base Information

Chemical Name:3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile
CAS No.:1171370-38-9
Molecular Formula:C₂₇H₂₆N₂O₅
Molecular Weight:458.514
Hs Code.:

Synonyms:3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

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Chemical Property of 3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

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Technology Process of 3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

There total 5 articles about 3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline

: 1711-11-1
3-cyanobenzoyl chloride

: 1171370-38-9
3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jm400177t

Reference yield:

: 1323416-78-9
C₁₉H₂₁NO₄

: 1171370-38-9
3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm400177t

Reference yield:

: 14301-31-6
2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide

: 1171370-38-9
3-(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / acetonitrile / 2 h / 20 °C

1.2: 18 h / Inert atmosphere

2.1: trichlorophosphate / toluene / 1.5 h / Reflux

3.1: sodium tetrahydroborate / methanol / 18 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; caesium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm400177t