(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

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Chemical Name:(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one
CAS No.:406676-52-6
Molecular Formula:C₂₆H₄₀O₄S₂Si
Molecular Weight:508.819
Hs Code.:

Synonyms:(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

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Chemical Property of (S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

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Technology Process of (S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

There total 7 articles about (S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 406676-45-7
(5S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3,5-dihydroxy-8-[2-((E)-styryl)-[1,3]dithian-2-yl]-octanoic acid ethyl ester

: 406676-52-6
(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(01)00506-7

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 406676-52-6
(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 70 percent / ceric ammonium nitrate / CHCl₃ / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.42 h / -78 °C

2.2: 58 percent / BF₃*Et₂O / tetrahydrofuran / 1 h

3.1: 81 percent / imidazole / CH₂Cl₂ / 20 °C

4.1: 95 percent / aq. CF₃COOH / CHCl₃ / 2 h / 0 °C

5.1: NaH / tetrahydrofuran / 0 °C

5.2: n-BuLi / tetrahydrofuran; hexane / -10 °C

5.3: 250 mg / tetrahydrofuran; hexane / 1 h / -50 °C

6.1: 93 percent / NaBH₄ / tetrahydrofuran / 1 h / -40 °C

7.1: 54 percent / p-toluenesulfonic acid / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; ammonium cerium(IV) nitrate; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1016/S0957-4166(01)00506-7

Reference yield:

: 69178-10-5
2-styryl-1,3-dithiane

: 406676-52-6
(S)-6-{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[2-((E)-styryl)-[1,3]dithian-2-yl]-propyl}-4-hydroxy-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.42 h / -78 °C

1.2: 58 percent / BF₃*Et₂O / tetrahydrofuran / 1 h

2.1: 81 percent / imidazole / CH₂Cl₂ / 20 °C

3.1: 95 percent / aq. CF₃COOH / CHCl₃ / 2 h / 0 °C

4.1: NaH / tetrahydrofuran / 0 °C

4.2: n-BuLi / tetrahydrofuran; hexane / -10 °C

4.3: 250 mg / tetrahydrofuran; hexane / 1 h / -50 °C

5.1: 93 percent / NaBH₄ / tetrahydrofuran / 1 h / -40 °C

6.1: 54 percent / p-toluenesulfonic acid / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium hydride; toluene-4-sulfonic acid; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1016/S0957-4166(01)00506-7