cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

Base Information

Chemical Name:cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide
CAS No.:1026688-27-6
Molecular Formula:C₃₂H₃₁NO₄
Molecular Weight:493.602
Hs Code.:

cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2<i>H</i>-chromen-7-ylmethyl)-amide

Synonyms:cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

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Chemical Property of cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

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Technology Process of cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

There total 6 articles about cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 19955-99-8
3-ethenylbenzaldehyde

: 698362-77-5
cyclopropanecarboxylic acid (3-bromo-phenyl)-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

: 1026688-27-6
cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

Guidance literature:: With triethylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1039/b300525a

Reference yield:

: 310404-31-0
8-methoxy-2,2-dimethyl-2H-chromene-7-carbaldehyde

: 1026688-27-6
cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 4 h / 70 °C

2: NaCNBH₃ / methanol / 4 h / 70 °C

3: Et₃N; 4-DMAP / CH₂Cl₂ / 12 h / 25 °C

4: 85 percent / Et₃N; P(o-tol)3 / Pd₂(dba)3 / dimethylformamide / 24 h / 90 °C

With dmap; sodium cyanoborohydride; triethylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4: Heck coupling;
DOI:10.1039/b300525a

Reference yield:

: 698362-73-1
(3-bromo-phenyl)-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amine

: 1026688-27-6
cyclopropanecarboxylic acid {3-[2-(3-formyl-phenyl)-vinyl]-phenyl}-(8-methoxy-2,2-dimethyl-2H-chromen-7-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; 4-DMAP / CH₂Cl₂ / 12 h / 25 °C

2: 85 percent / Et₃N; P(o-tol)3 / Pd₂(dba)3 / dimethylformamide / 24 h / 90 °C

With dmap; triethylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; 2: Heck coupling;
DOI:10.1039/b300525a