4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

Base Information

Chemical Name:4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine
CAS No.:1609258-91-4
Molecular Formula:C₁₉H₁₇N₅O
Molecular Weight:331.377
Hs Code.:

Synonyms:4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

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Chemical Property of 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

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Technology Process of 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

There total 6 articles about 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1609259-58-6
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine

: 1609258-91-4
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 45h;

Reference yield:

: 2-(2-methyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1609258-91-4
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,4-dioxane; ethyl acetate; Petroleum ether / 4 h / Reflux

2.1: boron tribromide / dichloromethane / 16 h / -70 - 20 °C / pH 8

3.1: palladium diacetate; caesium carbonate / 1,4-dioxane / 0.17 h / Sealed tube; Inert atmosphere

3.2: 3 h / 100 °C / Inert atmosphere; Sealed tube

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 45 h / 0 - 20 °C

With hydrogenchloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; boron tribromide; caesium carbonate; In 1,4-dioxane; dichloromethane; water; ethyl acetate; Petroleum ether;

Reference yield:

: 1609259-54-2
5-(4-methoxy-2-methylphenyl)-4,6-dimethylpyrimidine

: 1609258-91-4
4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 16 h / -70 - 20 °C / pH 8

2.1: palladium diacetate; caesium carbonate / 1,4-dioxane / 0.17 h / Sealed tube; Inert atmosphere

2.2: 3 h / 100 °C / Inert atmosphere; Sealed tube

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 45 h / 0 - 20 °C

With hydrogenchloride; palladium diacetate; boron tribromide; caesium carbonate; In 1,4-dioxane; dichloromethane;