Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester
CAS No.:151707-19-6
Molecular Formula:C₂₈H₄₀N₂O₇Si
Molecular Weight:544.72
Hs Code.:

Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

Synonyms:Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

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Chemical Property of Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

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Technology Process of Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

There total 11 articles about Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 624-83-9
methyl isocyanate

: 151707-18-5
(2R,3R,4S,5R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-6,6-dimethyl-tetrahydro-pyran-3,4-diol

: 151707-19-6
Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; Heating;
DOI:10.1016/S0040-4039(00)60620-2

Reference yield:

: 71312-15-7,93748-45-9,131423-76-2
1-benzyloxy-2,3-epoxy-3-methylbutane

: 151707-19-6
Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: aq. HClO₄ / 2-methyl-propan-2-ol

2: imidazole / dimethylformamide

3: H₂ / Pd(OH)2 / ethanol

4: Dess-Matin periodinane / CH₂Cl₂

5: K₂CO₃, 18-crown-6 / toluene

6: 100 percent / PPTS / benzene

7: DIBAL / toluene

8: TsOH

9: 52 percent / NMO / OsO₄ / acetone; H₂O

10: 85 percent / Et₃N / dioxane / Heating

With 1H-imidazole; perchloric acid; N-methyl-2-indolinone; 18-crown-6 ether; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; palladium dihydroxide; osmium(VIII) oxide; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)60620-2

Reference yield:

: 62748-09-8
[(2R)-3,3-dimethyloxiran-2-yl]methanol

: 151707-19-6
Methyl-carbamic acid (3R,4S,5R,6R)-3-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-2,2-dimethyl-5-methylcarbamoyloxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1: KH / tetrahydrofuran

2: aq. HClO₄ / 2-methyl-propan-2-ol

3: imidazole / dimethylformamide

4: H₂ / Pd(OH)2 / ethanol

5: Dess-Matin periodinane / CH₂Cl₂

6: K₂CO₃, 18-crown-6 / toluene

7: 100 percent / PPTS / benzene

8: DIBAL / toluene

9: TsOH

10: 52 percent / NMO / OsO₄ / acetone; H₂O

11: 85 percent / Et₃N / dioxane / Heating

With 1H-imidazole; perchloric acid; N-methyl-2-indolinone; 18-crown-6 ether; hydrogen; pyridinium p-toluenesulfonate; potassium hydride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; palladium dihydroxide; osmium(VIII) oxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)60620-2