4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid

Base Information

• Chemical Name: 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid
• CAS No.: 1310680-18-2
• Molecular Formula: C₁₁H₂₁NO₄
• Molecular Weight: 231.292
• Mol file: 1310680-18-2.mol

Synonyms:4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid

Chemical Property of 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Boc-4-amino-3,3-dimethyl-butyricacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid

There total 8 articles about 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-(tert-butoxycarbonylamino)-3,3-dimethylbutanoate → 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid (1310680-18-2)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃;

Reference yield: 20.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-amino-3,3-dimethylbutanoic acid hydrochloride → 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid (1310680-18-2)

Guidance literature:

With sodium hydroxide; In tert-butyl alcohol; at 20 ℃; for 4h;

Reference yield:

ethyl 3-methylbut-2-enoate (638-10-8) → 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid (1310680-18-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 120 h / 60 °C

2: 5%-palladium/activated carbon; hydrogen; acetic acid / ethanol / 5 h / 70 °C / 3750.38 Torr

3: toluene / 20 h / 20 °C

4: sodium hydroxide / ethanol / 20 °C

With 5%-palladium/activated carbon; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; toluene; acetonitrile;

upstream raw materials:

di-tert-butyl dicarbonate

4-amino-3,3-dimethylbutanoic acid ethyl ester

ethyl 3-methylbut-2-enoate

3,3-dimethyl-4-nitro-butyric acid ethyl ester

Downstream raw materials:

4-nitrophenyl 4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoate