3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

Base Information

Chemical Name:3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate
CAS No.:145235-60-5
Molecular Formula:C₁₇H₁₈N₂O₆S
Molecular Weight:378.406
Hs Code.:

Synonyms:3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

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Chemical Property of 3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

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Technology Process of 3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

There total 2 articles about 3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 145235-59-2,145307-14-8
2,2-Dibenzyl 3-Methyl (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,2,3-tricarboxylate

: 145235-60-5
3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

Guidance literature:: With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; at 45 ℃; for 5h; under 3102.9 Torr;
DOI:10.1002/hlca.19920750610

Reference yield:

: 145235-58-1
2-Benzyloxycarbonyl-3-methanesulfonyloxy-2-((2S,3S)-2-methanesulfonyloxymethyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-succinic acid 1-benzyl ester 4-methyl ester

: 145235-60-5
3-Methyl 2-Hydrogen (6RS,7RS)-8-Oxo-7-(phenylacetamido)-4-thia-1-azabicyclo<4.2.0>octane-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / (Me₃Sn)2S, Bu₄NF / tetrahydrofuran / 1 h / 25 °C

2: 52 percent / H₂, 1percent aq. NaHCO₃ / 10percent Pd/C / methanol / 5 h / 45 °C / 3102.9 Torr

With tetrabutyl ammonium fluoride; hydrogen; bis(trimethyltin) sulfide; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1002/hlca.19920750610