Technology Process of 4-Bromophenylboronic acid
There total 24 articles about 4-Bromophenylboronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1.4-dibromobenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -30 ℃;
Inert atmosphere;
Flow reactor;
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -30 ℃;
Inert atmosphere;
Flow reactor;
DOI:10.1021/acs.orglett.6b01681
- Guidance literature:
-
1.4-dibromobenzene;
With
n-butyllithium;
In
diethyl ether;
at -78 - 20 ℃;
Inert atmosphere;
With
Triisopropyl borate;
In
diethyl ether;
at -78 - 20 ℃;
Inert atmosphere;
With
hydrogenchloride; water;
at 0 ℃;
DOI:10.1021/ja908915v
- Guidance literature:
-
With
water;
In
tetrahydrofuran;
slow addn. of 10 mmol of the Grignard reagent to a stirred soln. of borane in THF (40 mmol); the mixt. was poured into ice-water and acidified with 10% HCl;; extn. into ether three-times; the combined extracts were dried over NaSO4; removal of solvent under reduced pressure; trituration with petroleum ether; recrystn. from H2O;;
DOI:10.1016/0022-328X(83)87176-9
Xi
