3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile

Base Information

• Chemical Name: 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile
• CAS No.: 1616087-73-0
• Molecular Formula: C₂₂H₁₅BrCl₂N₄S
• Molecular Weight: 518.264
• Mol file: 1616087-73-0.mol

Synonyms:3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile

Chemical Property of 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile

There total 4 articles about 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidine-2-thiol (1616087-50-3) + acrylonitrile (107-13-1,25014-41-9) → 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile (1616087-73-0)

Guidance literature:

With pyridine; for 20h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2014.05.002

Reference yield:

C18H10BrCl2NO (1616087-35-4) → 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile (1616087-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 6 h / Reflux; Inert atmosphere

2: pyridine / 20 h / Reflux; Inert atmosphere

With pyridine; potassium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2014.05.002

Reference yield:

2,6-dichloroquinoline-3-carbaldehyde (73568-41-9) → 3-((4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidin-2-yl)thio)propanenitrile (1616087-73-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 24 h / Inert atmosphere

2: potassium hydroxide / ethanol / 6 h / Reflux; Inert atmosphere

3: pyridine / 20 h / Reflux; Inert atmosphere

With pyridine; potassium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmcl.2014.05.002

upstream raw materials:

C₁₈H₁₀BrCl₂NO

2,6-dichloroquinoline-3-carbaldehyde

1-(3-Bromophenyl)ethanone

4-(3-bromophenyl)-6-(2,6-dichloroquinolin-3-yl)-1,6-dihydropyrimidine-2-thiol