monofluoroketene hemithioacetal

Base Information

• Chemical Name: monofluoroketene hemithioacetal
• CAS No.: 108200-51-7
• Molecular Formula: C₁₃H₁₇FOS
• Molecular Weight: 240.342
• Mol file: 108200-51-7.mol

Synonyms:monofluoroketene hemithioacetal

Chemical Property of monofluoroketene hemithioacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of monofluoroketene hemithioacetal

There total 2 articles about monofluoroketene hemithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

n-butyllithium (109-72-8,29786-93-4) + Phenyl 1-methoxy-2,2,2-trifluoroethyl sulfide (108200-49-3) → 1-Methoxy-1-(phenylthio)-2-fluoro-1-hexene (108200-51-7)

Guidance literature:

In diethyl ether; hexane; at -78 ℃; for 3h;

DOI:10.1021/jo00001a028

Reference yield: 70.0%

n-butyllithium (109-72-8,29786-93-4) + Phenyl 1-methoxy-2,2,2-trifluoroethyl sulfide (108200-49-3) → monofluoroketene hemithioacetal (108200-51-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1016/S0040-4039(00)83902-7

Reference yield: 95.0%

1-Methoxy-1-(phenylthio)-2-fluoro-1-hexene (108200-51-7) → α-fluorohexanoic acid (1578-57-0)

Guidance literature:

With sulfuric acid; at 50 ℃; for 5h;

DOI:10.1021/jo00001a028

upstream raw materials:

n-butyllithium

Phenyl 1-methoxy-2,2,2-trifluoroethyl sulfide

Downstream raw materials:

α-fluorohexanoic acid