ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

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Chemical Name:ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate
CAS No.:1311157-88-6
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:

Synonyms:ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

There total 5 articles about ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1311157-81-9
ethyl 3-(1H-indol-3-yl)-1-propyl-1H-pyrazole-5-carboxylate

: 1311157-88-6
ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

Guidance literature:: ethyl 3-(1H-indol-3-yl)-1-propyl-1H-pyrazole-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 10 ℃; for 0.166667h;

1-(halomethyl)-4-methoxybenzene; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1007/s12272-011-0301-2

Reference yield:

: 1311157-81-9
ethyl 3-(1H-indol-3-yl)-1-propyl-1H-pyrazole-5-carboxylate

: 2746-25-0
p-Methoxybenzyl bromide

: 1311157-88-6
ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

Guidance literature:: ethyl 3-(1H-indol-3-yl)-1-propyl-1H-pyrazole-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 10 ℃; for 0.166667h;

p-Methoxybenzyl bromide; In N,N-dimethyl-formamide; at 10 - 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2011.09.049

Reference yield:

: 51843-30-2
C₁₄H₁₃N₃O₂

: 1311157-88-6
ethyl 3-[1-(4-methoxybenzyl)-indol-3-yl]-1-propyl-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium bromide; potassium hydroxide / dimethyl sulfoxide / 1.5 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 10 °C

2.2: 1 h / 10 - 20 °C

With sodium hydride; potassium bromide; potassium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.049