(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

Base Information

Chemical Name:(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde
CAS No.:1428872-64-3
Molecular Formula:C₃₆H₄₈N₂O₅S
Molecular Weight:620.854
Hs Code.:

Synonyms:(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

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Chemical Property of (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

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Technology Process of (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

There total 24 articles about (4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428872-55-2
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-4-[3-(1,3-dioxolan-2-yl)propyl]-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)perhydroisoquinoline

: 1428872-64-3
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3cc41104d

Reference yield:

: 101639-95-6
oct-7-enoyl chloride

: 1428872-64-3
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3cc41104d

Reference yield:

: 18719-24-9
oct-7-enoic acid

: 1428872-64-3
(4R,4aR,6S,7S,8aS)-7-(benzyloxy)-6,4-(iminomethano)-2-(7-octenoyl)-9-(p-toluenesulfonyl)-4-perhydroisoquinolinebutyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c3cc41104d