propionamidine hydrochloride

Base Information

• Chemical Name: propionamidine hydrochloride
• CAS No.: 3599-89-1
• Molecular Formula: C3H8 N2 . Cl H
• Molecular Weight: 108.571
• Hs Code.: 2925290090
• Mol file: 3599-89-1.mol

Synonyms:Propionamidine,hydrochloride (6CI,7CI,8CI); Propanamidine hydrochloride; Propioamidinehydrochloride

Chemical Property of propionamidine hydrochloride

Chemical Property:

• Vapor Pressure: 55.3mmHg at 25°C
• Melting Point: 298.5 °C
• Boiling Point: 90.8°Cat760mmHg
• Flash Point: 8.7°C
• PSA: 49.87000
• Density: 0.99g/cm³
• LogP: 1.93440
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

PropioamidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Propioamidine Hydrochloride acts as a reagent in the synthetic preparation of guanidine.

Technology Process of propionamidine hydrochloride

There total 3 articles about propionamidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

ethyl propanimidate hydrochloride (40546-35-8) → propionamidine hydrochloride (3599-89-1)

Guidance literature:

With ammonia; In ethanol;

Reference yield: 70.0%

propiononitrile (107-12-0) → propionamidine hydrochloride (3599-89-1)

Guidance literature:

propiononitrile; With hydrogenchloride; In ethanol; at 10 - 35 ℃; for 21.5h;

With ammonia; In methanol; ethanol; at 10 - 35 ℃; for 28h;

Reference yield:

methylpropioimidate hydrochloride (39739-45-2) → propionamidine hydrochloride (3599-89-1)

Guidance literature:

With ammonium hydroxide; In ethanol; for 24h; Yield given; Ambient temperature;

DOI:10.1021/jo00325a006

upstream raw materials:

propiononitrile

methylpropioimidate hydrochloride

ethyl propanimidate hydrochloride

Downstream raw materials:

2-ethyl-4-methyl-pyrimidine

N-phenyl-propionamidine

2-ethyl-6-methylpyrimidin-4-ol

p-trifluoromethylbenzamide

Refernces

• 1、 -. "PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY". Paragraph 0324. . Retrieved 2016/10/07.
• 2、 -. "TREATMENT OF CANCERS HAVING K-RAS MUTATIONS". Paragraph 0370; 0371. . Retrieved 2013/05/08.