methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

Base Information

• Chemical Name: methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate
• CAS No.: 1331836-43-1
• Molecular Formula: C₁₈H₁₉NO₅S
• Molecular Weight: 361.419

Synonyms:methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

Chemical Property of methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

There total 2 articles about methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carbaldehyde (1229516-61-3) → methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate (1331836-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 24 h / Reflux

2: 1,2-dichloro-ethane / 24 h / Reflux

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; 1,2-dichloro-ethane; 1: Suzuki-Miyaura coupling;

DOI:10.1021/ol201510u

Reference yield:

C13H11NO3S (1331836-53-3) + 2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-ylmethyl)-acrylic acid methyl ester → methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate (1331836-43-1)

Guidance literature:

In 1,2-dichloro-ethane; for 24h; Reflux;

DOI:10.1021/ol201510u

Reference yield: 70.0%

methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate (1331836-43-1) → methyl 2-methylene-4-oxo-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate (1331836-54-4)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 16h;

DOI:10.1021/ol201510u

upstream raw materials:

3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carbaldehyde

C₁₃H₁₁NO₃S

Downstream raw materials:

methyl 2-methylene-4-oxo-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1331836-43-1 methyl 4-hydroxy-2-methylene-4-(1-(phenylsulfonyl)-3-vinyl-1H-pyrrol-2-yl)butanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send