(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

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Chemical Name:(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate
CAS No.:1400877-53-3
Molecular Formula:C₁₇H₁₅BrN₄O₃
Molecular Weight:403.235
Hs Code.:

Synonyms:(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

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Chemical Property of (S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

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Technology Process of (S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

There total 7 articles about (S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.9%

: 1400580-11-1
6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carboxamide

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 1400877-53-3
(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 1h; Microwave irradiation;

Reference yield:

: 35302-72-8
pyrrol-2-yl trichloromethyl ketone

: 1400877-53-3
(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine; iodine / tetrachloromethane / 0.67 h / 0 °C

2.1: sodium / 0.17 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

3.3: 0.5 h

4.1: isopropyl alcohol / 3 h / 85 °C

4.2: 5 h / 85 °C

5.1: trichlorophosphate / dichloromethane / 3 h / 75 °C

5.2: 0 - 20 °C

6.1: sulfuric acid / 2 h / 55 °C

7.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 80 °C / Microwave irradiation

With sulfuric acid; bromine; iodine; sodium; sodium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;

Reference yield:

: 1400580-12-2
methyl 1-amino-4-bromo-1H-pyrrole-2-carboxylate methanesulfonic acid salt

: 1400877-53-3
(S)-methyl 2-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-2-phenylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 3 h / 85 °C

1.2: 5 h / 85 °C

2.1: trichlorophosphate / dichloromethane / 3 h / 75 °C

2.2: 0 - 20 °C

3.1: sulfuric acid / 2 h / 55 °C

4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 80 °C / Microwave irradiation

With sulfuric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; dichloromethane; isopropyl alcohol;