6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid

Base Information

Chemical Name:6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid
CAS No.:86696-71-1
Molecular Formula:C₁₅H₁₅NO₅
Molecular Weight:289.288
Hs Code.:
DSSTox Substance ID:DTXSID001217440

Synonyms:6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid;DTXSID001217440;86696-71-1

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Chemical Property of 6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:289.09502258
Heavy Atom Count:21
Complexity:337

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=NC(=CC=C2)C(=O)O

Technology Process of 6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid

There total 5 articles about 6-(3,4,5-Trimethoxyphenyl)-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Chloro-6-(3,4,5-trimethoxy-phenyl)-pyridine-2-carbonyl chloride

: 86696-71-1
6-(3,4,5-Trimethoxy-phenyl)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Heating

2: H₂, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr

3: 5percent methanolic KOH / 1 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00364a026

Reference yield:

: 4-Hydroxy-6-(3,4,5-trimethoxy-phenyl)-pyridine-2-carboxylic acid

: 86696-71-1
6-(3,4,5-Trimethoxy-phenyl)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 5 h / Heating

2: Heating

3: H₂, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr

4: 5percent methanolic KOH / 1 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00364a026

Reference yield:

: 4-Chloro-6-(3,4,5-trimethoxy-phenyl)-pyridine-2-carboxylic acid methyl ester

: 86696-71-1
6-(3,4,5-Trimethoxy-phenyl)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr

2: 5percent methanolic KOH / 1 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00364a026