2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine

Base Information

Chemical Name:2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine
CAS No.:174500-20-0
Molecular Formula:C23H19N3O2
Molecular Weight:369.423
Hs Code.:29349990
European Community (EC) Number:623-921-5
UNII:5R62CXU58K
DSSTox Substance ID:DTXSID60426601
Nikkaji Number:J816.108I
Wikidata:Q27262764
Mol file:174500-20-0.mol

Synonyms:174500-20-0;2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine;(S,S)-PH-PYBOX;2,6-Bis[(4S)-4-phenyl-2-oxazolinyl]pyridine;(-)-2,6-BIS[(4S)-4-PHENYL-2-OXAZOLIN-2-YL]PYRIDINE;Ph-pybox, (S,S)-;2,6-Bis[(4S)-phenyl-2-(oxazolin-2-yl)]pyridine;(S,S)-Phenyl-pybox;(S,S)-Ph-pybox [MI];2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine;Ph-pybox, (S,S)-(-)-;Pyridine, 2,6-bis[(4S)-4,5-dihydro-4-phenyl-2-oxazolyl]-;UNII-5R62CXU58K;(S,S)-2,6-Bis(4-phenyl-2-oxazolin-2-yl)pyridine;5R62CXU58K;2,6-Bis((S)-4-phenyl-2-oxazolin-2-yl)pyridine;2,6-Bis((4S)-4-phenyl-2-oxazolin-2-yl)pyridine;2,6-Bis((4S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine;Pyridine, 2,6-bis((4S)-4,5-dihydro-4-phenyl-2-oxazolyl)-;(S,S)-2,6-Bis(4-phenyl-2-oxazolinyl)pyridine;(4S)-4-phenyl-2-[6-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridin-2-yl]-4,5-dihydro-1,3-oxazole;(S,S)-2,6-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine;MFCD01863586;(S,S)-2,2'-(2,6-Pyridinediyl)bis(4-phenyl-2-oxazoline);2,6-bis[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine;SCHEMBL918823;DTXSID60426601;HLHBIMJNCKZZQO-NHCUHLMSSA-N;AMY41348;AKOS016842266;CS-W008090;DS-3690;SC11778;AC-22427;BP-12297;B2220;2,6-bis[(4S)-phenyl-2-oxazoline-2-yl]pyridine;A811647;2,6-Bis[((4S)-Phenyl)-2-oxazolin-2-yl]pyridine;J-005581;J-010994;2,6-Bis[(4S)-4-phenyl-2-oxazolinyl]pyridine, 98%;Q27262764;2,6-Bis(4S)(4-phenyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine;(4S)-4-phenyl-2-[6-[(4S)-4-phenyl-4,5-dihydrooxazol-2-yl]-2-pyridyl]-4,5-dihydrooxazole

Suppliers and Price of 2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine
2.5mg
$ 45.00

TCI Chemical
(S,S)-2,6-Bis(4-phenyl-2-oxazolin-2-yl)pyridine >95.0%(HPLC)
1g
$ 187.00

TCI Chemical
(S,S)-2,6-Bis(4-phenyl-2-oxazolin-2-yl)pyridine >95.0%(HPLC)
250mg
$ 64.00

SynChem
2,6-Bis[(4S)-phenyl-2-(oxazolin-2-yl)]pyridine 98+%, 98+%ee
5 g
$ 450.00

SynChem
2,6-Bis[(4S)-phenyl-2-(oxazolin-2-yl)]pyridine 98+%, 98+%ee
10 g
$ 750.00

SynChem
2,6-Bis[(4S)-phenyl-2-(oxazolin-2-yl)]pyridine 98+%, 98+%ee
1 g
$ 150.00

Strem Chemicals
2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine, 98%, (99% ee)
1g
$ 114.00

Strem Chemicals
(-)-2,6-Bis[(4S)-4-phenyl-2-oxazolin-2-yl]pyridine, 98+% (S,S)-Ph-pybox
500mg
$ 143.00

Strem Chemicals
(-)-2,6-Bis[(4S)-4-phenyl-2-oxazolin-2-yl]pyridine, 98+% (S,S)-Ph-pybox
2g
$ 426.00

Sigma-Aldrich
2,6-Bis[(4S)-4-phenyl-2-oxazolinyl]pyridine 98%
2g
$ 433.00

Total 50 raw suppliers

Chemical Property of 2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Melting Point:171-175 °C(lit.)
Boiling Point:600.4 °C at 760 mmHg
PKA:3.07±0.70(Predicted)
Flash Point:316.9 °C
PSA：56.07000
Density:1.28 g/cm³
LogP:2.98900
Storage Temp.:Refrigerator
Water Solubility.:Insoluble
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:369.147726857
Heavy Atom Count:28
Complexity:543

Purity/Quality:

97% ^*data from raw suppliers

2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1C(N=C(O1)C2=NC(=CC=C2)C3=NC(CO3)C4=CC=CC=C4)C5=CC=CC=C5
Isomeric SMILES:C1[C@@H](N=C(O1)C2=NC(=CC=C2)C3=N[C@H](CO3)C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of 2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine

There total 8 articles about 2,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2893-33-6
pyridine-2,6-dinitrile

: 20989-17-7
(2S)-2-phenylglycinol

: 174500-20-0
(S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine

Guidance literature:: With zinc trifluoromethanesulfonate; In toluene; for 48h; Heating;
DOI:10.1055/s-2005-872672

Reference yield: 72.0%

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 56613-81-1,1936-63-6
(S)-2-Amino-1-phenyl-1-ethanol

: 174500-20-0
(S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine

Guidance literature:: 2,6-Pyridinedicarbonyl dichloride; (S)-2-Amino-1-phenyl-1-ethanol; With potassium hydrogencarbonate; In Isopropyl acetate; at 80 ℃; for 2h;

With dmap; TEA; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 40.6667h; Further stages.;
DOI:10.1021/ol005721h

Reference yield: 70.0%

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 20989-17-7
(2S)-2-phenylglycinol

: 174500-20-0
(S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine

Guidance literature:: 2,6-Pyridinedicarbonyl dichloride; (2S)-2-phenylglycinol; With triethylamine; In dichloromethane; at 20 ℃; for 3h;

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 24h;
DOI:10.1016/S0040-4039(03)00937-7