(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
CAS No.:1620015-17-9
Molecular Formula:C₂₃H₂₄F₂N₆O₂S
Molecular Weight:486.545
Hs Code.:

(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Synonyms:(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Suppliers and Price of (3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

There total 22 articles about (3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₀F₂N₆O₆S

: 1620015-17-9
(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: With trifluoroacetic acid; at 20 - 30 ℃; for 1h;

Reference yield:

: 1312789-31-3,167832-26-0,1932598-12-3
(+/-)-benzyl 3-amino-4-hydroxypiperidine-1-carboxylate

: 1620015-17-9
(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / dichloromethane / 2 h / 20 - 30 °C

2: triethylamine / dichloromethane / 18 h / 20 - 30 °C

3: pyridine / 2 h / 120 °C

4: dmap; triethylamine / dichloromethane / 18 h / 20 - 30 °C

5: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h / 1292.9 Torr

6: triethylamine / isopropyl alcohol / 18 h / 70 °C

7: iron; acetic acid / water / 1 h / 20 - 30 °C

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 - 30 °C

9: caesium carbonate / methanol / 0.5 h / 80 °C

10: trifluoroacetic acid / 1 h / 20 - 30 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; iron; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1052715-48-6
(3R,4R)-benzyl 3-(tert-butoxycarbonylamino)-4-(methylsulfonyloxy)-piperidine-1-carboxylate

: 1620015-17-9
(3R,5S)-5-amino-N-{4-[3,4-cis-3-amino-4-hydroxypiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / 2 h / 120 °C

2: dmap; triethylamine / dichloromethane / 18 h / 20 - 30 °C

3: hydrogen; palladium 10% on activated carbon / methanol; ethyl acetate / 1 h / 1292.9 Torr

4: triethylamine / isopropyl alcohol / 18 h / 70 °C

5: iron; acetic acid / water / 1 h / 20 - 30 °C

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 - 30 °C

7: caesium carbonate / methanol / 0.5 h / 80 °C

8: trifluoroacetic acid / 1 h / 20 - 30 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; iron; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;