ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate
• CAS No.: 1247019-54-0
• Molecular Formula: C₂₂H₁₉FN₂O₅
• Molecular Weight: 410.402
• Mol file: 1247019-54-0.mol

Synonyms:ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property of ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 2 articles about ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-tolyltrimethylstannane (937-12-2) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester (111453-55-5) → ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1247019-54-0)

Guidance literature:

With palladium diacetate; cesium fluoride; In N,N-dimethyl-formamide; at 90 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.06.098

Reference yield:

4-methylphenylboronic acid (5720-05-8) + 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester (111453-55-5) → ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1247019-54-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.08.065

Reference yield: 88.0%

ethyl 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate (1247019-54-0) → 1-cyclopropyl-6-fluoro-7-(4-methylphenyl)-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:

With hydrogenchloride; water; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2014.08.065

upstream raw materials:

4-tolyltrimethylstannane

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester

4-methylphenylboronic acid