N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine

Base Information

• Chemical Name: N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine
• CAS No.: 107961-43-3
• Molecular Formula: C₂₆H₃₂N₆O₇
• Molecular Weight: 540.576

Synonyms:N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine

Chemical Property of N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine

Chemical Property:

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Technology Process of N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine

There total 2 articles about N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-benzoyl-5'(R)-C-(nitromethyl)-2',3'-O-isopropylideneadenosine (84757-69-7) → N6-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine (107961-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / methanol / 16 h / 20 °C / 2585.7 Torr

2: CH₂Cl₂ / 1 h / 20 °C

With hydrogen; platinum(IV) oxide; In methanol; dichloromethane;

DOI:10.1021/jm00388a024

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + N-{9-[(3aR,4R,6R,6aR)-6-((R)-2-Amino-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-9H-purin-6-yl}-benzamide → N6-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine (107961-43-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h; Yield given;

DOI:10.1021/jm00388a024

Reference yield: 85.0%

p-toluenesulfonyl chloride (98-59-9) + N6-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylideneadenosine (107961-43-3) → N6-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)adenosine (107961-45-5)

Guidance literature:

With pyridine; at 20 ℃; for 28h;

DOI:10.1021/jm00388a024

upstream raw materials:

di-tert-butyl dicarbonate

N⁶-benzoyl-5'(R)-C-(nitromethyl)-2',3'-O-isopropylideneadenosine

Downstream raw materials:

N⁶-benzoyl-5'(R)-C-<methyl>-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)adenosine

N⁶-benzoyl-5'(S)-5'--2',3'-O-isopropylidene-5',5'-C,N-methylideneadenosine

N⁶-benzoyl-5'(S)-C-<methyl>-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)adenosine

N⁶-benzoyl-5'(S)-C-<methyl>-2',3'-O-isopropylideneadenosine

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