1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

Base Information

Chemical Name:1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one
CAS No.:380415-76-9
Molecular Formula:C₃₄H₄₉N₃O₃
Molecular Weight:547.781
Hs Code.:

Synonyms:1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

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Chemical Property of 1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

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Technology Process of 1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

There total 8 articles about 1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 53880-65-2
benzyl (4-iodobutyl)carbamate

: 380415-75-8
1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

: 380415-76-9
1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

Guidance literature:: 1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one; With sodium hydride; In N,N-dimethyl-formamide;

benzyl (4-iodobutyl)carbamate; Further stages.;
DOI:10.1021/ol016394w

Reference yield:

: 13139-15-6,53296-34-7
Boc-DL-Leu-OH

: 380415-76-9
1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 25 percent / DCC; DMAP / CH₂Cl₂

2: TFA / CH₂Cl₂

3: AcOH / dimethylformamide

4: 44 percent / NaH / dimethylformamide

With dmap; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol016394w

Reference yield:

: 764-93-2
1-decyne

: 380415-76-9
1-benzyloxycarbonylaminobutyl-1,3-dihydro-3-(2-methylpropyl)-5-nonyl-benzo-1,4-diazepine-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / [PdCl₂(PPh₃)2]; CuI; Et₂NH

2: 100 percent / Na₂S; HCl / methanol; H₂O

3: 25 percent / DCC; DMAP / CH₂Cl₂

4: TFA / CH₂Cl₂

5: AcOH / dimethylformamide

6: 44 percent / NaH / dimethylformamide

With hydrogenchloride; dmap; sodium sulfide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; acetic acid; diethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol016394w