α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

Base Information

Chemical Name:α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester
CAS No.:158220-92-9
Molecular Formula:C₂₆H₃₄N₂O₇
Molecular Weight:486.565
Hs Code.:

Synonyms:α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

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Chemical Property of α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

Chemical Property:

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Technology Process of α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

There total 4 articles about α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 158220-91-8
α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine

: 908093-98-1
diazodiphenylmethane

: 158220-92-9
α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

Guidance literature:: In acetonitrile; for 1h;
DOI:10.1016/S0040-4020(01)90416-8

Reference yield:

: 36016-38-3
tert-Butyl N-hydroxycarbamate

: 158220-92-9
α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / 1-ethyl-3-<3-(dimethylamino)propyl>-carbodiimide / CH₂Cl₂ / 15 h

2: 1.) 50percent sodium hydride in mineral oil, 2.) caesium carbonate / 1.) dimethylformamide, 0 deg C, 1 h, 2.) water, dimethylformamide, 10 min

3: 93 percent / acetonitrile / 1 h

With sodium hydride; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)90416-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 158220-92-9
α-(N-tert-butoxycarbonyl)-β-(N-tert-butoxycarbonyl, N-hydroxy)-β-amino-L-alanine benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / hydroxylamine hydrochloride, 2N aq. NaOH / dioxane / 22 h

2: 91 percent / 1-ethyl-3-<3-(dimethylamino)propyl>-carbodiimide / CH₂Cl₂ / 15 h

3: 1.) 50percent sodium hydride in mineral oil, 2.) caesium carbonate / 1.) dimethylformamide, 0 deg C, 1 h, 2.) water, dimethylformamide, 10 min

4: 93 percent / acetonitrile / 1 h

With sodium hydroxide; hydroxylamine hydrochloride; sodium hydride; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)90416-8