4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide

Base Information

• Chemical Name: 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide
• CAS No.: 1432601-31-4
• Molecular Formula: C₂₇H₂₄BrFN₂O₂
• Molecular Weight: 507.402

Synonyms:4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide

Chemical Property of 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide

There total 10 articles about 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-methoxy-N-(2-methylpropylidene)aniline oxide (1432601-18-7) → 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide (1432601-31-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: magnesium iodide / toluene / 20 °C / Molecular sieve; Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / acetonitrile / 3 h / 80 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydroxide / methanol / 20 h / 100 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

6.1: thionyl chloride / tetrahydrofuran / Inert atmosphere; Reflux

7.1: 12 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; magnesium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1002/anie.201206177

Reference yield:

(3RS,6RS)-4-allyl 4-methyl 6-(4-fluorophenyl)-3-isopropyl-2-(4-methoxyphenyl)-1,2-oxazinane-4,4-dicarboxylate → 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide (1432601-31-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / acetonitrile / 3 h / 80 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.08 h / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / methanol / 20 h / 100 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: thionyl chloride / tetrahydrofuran / Inert atmosphere; Reflux

6.1: 12 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201206177

Reference yield:

4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-1H-pyrrole-3-carboxylic acid (1432601-29-0) → 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide (1432601-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / Inert atmosphere; Reflux

2: 12 h / Inert atmosphere; Reflux

With thionyl chloride; In tetrahydrofuran;

DOI:10.1002/anie.201206177

upstream raw materials:

(E)-4-methoxy-N-(2-methylpropylidene)aniline oxide

methyl 5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-1H-pyrrole-3-carboxylate

4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-1H-pyrrole-3-carboxylic acid

p-methoxyphenylhydroxylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1432601-31-4 4-bromo-5-(4-fluorophenyl)-2-isopropyl-1-(4-methoxyphenyl)-N-phenyl-1H-pyrrole-3-carboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send