4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride

Base Information

• Chemical Name: 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride
• CAS No.: 1620775-47-4
• Molecular Formula: C₂₁H₁₆Cl₂F₃N₅O₂
• Molecular Weight: 500.276

Synonyms:4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride

Chemical Property of 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride

Chemical Property:

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MSDS Files:

Useful:

Technology Process of 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride

There total 5 articles about 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoic acid (1620775-42-9) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoyl chloride (1620775-47-4)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 90 ℃; for 16h; Sealed tube;

Reference yield:

C5(2)H2Cl2F3N3O (1620775-44-1) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoyl chloride (1620775-47-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 70 °C

3.1: potassium carbonate / acetone; water / 16 h / 80 °C / Sealed tube

3.2: pH 2

4.1: sulfuryl dichloride / dichloromethane / 16 h / 90 °C / Sealed tube

With sulfuryl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;

Reference yield:

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoate (1620775-45-2) → 4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D2)-1,3,5-triazin-2-ylamino)benzoyl chloride (1620775-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 70 °C

2.1: potassium carbonate / acetone; water / 16 h / 80 °C / Sealed tube

2.2: pH 2

3.1: sulfuryl dichloride / dichloromethane / 16 h / 90 °C / Sealed tube

With sulfuryl dichloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; acetone;

upstream raw materials:

C₅⁽²⁾H₂Cl₂F₃N₃O

methyl 4-(4-chloro-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoate

4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzoic acid

4-methoxycarbonyl aniline

Downstream raw materials:

2-(4-(4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy-D₂)-1,3,5-triazin-2-ylamino)benzamido)-N,N,N-trimethylethanaminium

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