Technology Process of C7(2)H5BrO
There total 2 articles about C7(2)H5BrO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,4-dibromotetradeuterobenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.416667h;
d7-N,N-dimethylformamide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 3h;
Further stages.;
DOI:10.1021/ja993844v
- Guidance literature:
-
4-bromobenzoic-2,3,5,6-d4 acid;
With
sodium borodeuteride; iodine;
In
tetrahydrofuran;
for 0.5h;
Cooling with ice;
In
tetrahydrofuran;
for 12h;
Reflux;
With
sodium acetate; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 3h;
Molecular sieve;
DOI:10.1021/acs.joc.1c02086
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: p-toluenesulfonic acid / benzene / 10 h / Heating
2.1: BuLi / tetrahydrofuran; hexane / 25 h / -78 °C
2.2: 68 percent / (CH3O)3(11)B / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
With
n-butyllithium; toluene-4-sulfonic acid;
In
tetrahydrofuran; hexane; benzene;
1.1: Addition / 2.1: Dehalogenation / 2.2: Addition;
DOI:10.1021/ja993844v