(2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Base Information

• Chemical Name: (2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine
• CAS No.: 146099-04-9
• Molecular Formula: C₂₂H₂₇N
• Molecular Weight: 305.463
• Mol file: 146099-04-9.mol

Synonyms:(2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Chemical Property of (2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine

There total 1 articles about (2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylmagnesium bromide (1589-82-8) + (+)-3,4-dimethyl-1-<(1R)-1-phenylethyl>pyridinium dodecylsulfate → (2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine (146099-04-9)

Guidance literature:

With sodium tetrahydroborate; Yield given. Multistep reaction; 1a.) THF, Et₂O, -78 deg C, 0.5 h, 1b.) 0 deg C, 2 h, 2.) Et₂O, MeOH, water, reflux, 1 h;

DOI:10.1021/jo00060a019

Reference yield: 47.0%

(2S)-(-)-3,4-dimethyl-2-(phenylmethyl)-1-<(1R)-1-phenylethyl>-1,2,5,6-tetrahydropyridine (146099-04-9) → (1S,5S,9S)-(+)-5,9-dimethyl-2-<(1R)-1-phenylethyl>-6,7-benzomorphan (146099-06-1)

Guidance literature:

With phosphoric acid; at 140 - 145 ℃; for 60h;

DOI:10.1021/jo00060a019

upstream raw materials:

phenylmagnesium bromide

Downstream raw materials:

(1S,5S,9S)-(+)-5,9-dimethyl-2-<(1R)-1-phenylethyl>-6,7-benzomorphan