Chemical Property of Bonannione A
Chemical Property:
- Appearance/Colour:White to off-white crystalline powder
- Boiling Point:523.3 °C at 760 mmHg
- Flash Point:270.3 °C
- PSA：155.10000
- Density:1.454 g/cm3
- LogP:8.40910
- Storage Temp.:2-8°C(protect from light)
- Solubility.:Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).
- XLogP3:6.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:408.19367399
- Heavy Atom Count:30
- Complexity:642
- Purity/Quality:
-
99%, *data from raw suppliers
Sorafenib tosylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Statements:
36/37/38
- Safety Statements:
28-26
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CCCC(=CCC1=C(C2=C(C=C1O)OC(CC2=O)C3=CC=C(C=C3)O)O)C)C
- Isomeric SMILES:CC(=CCC/C(=C/CC1=C(C2=C(C=C1O)O[C@@H](CC2=O)C3=CC=C(C=C3)O)O)/C)C
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Description
Sorafenib (475207-59-1) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM).1?Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms.2?Inhibits activation of MAPK pathway and ERK phosphorylation.3?Induces caspase-independent apoptosis in melanoma cells.4?Sorafenib is a clinically useful anticancer agent.
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Uses
Sorafenib Tosylate (Bay 43-9006) is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.
