(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1160437-99-9
Molecular Formula:C₄₂H₆₃N₃O₈
Molecular Weight:737.978
Hs Code.:

(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Synonyms:(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 14 articles about (3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1160438-00-5
(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl-methoxy]-5-((E)-3-oxo-3-pyrrolidin-1-yl-propenyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1160437-99-9
(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 15 - 20 ℃; for 2 - 20h;

Reference yield:

: 109989-31-3
methyl (R)-2-ethoxypropanoate

: 1160437-99-9
(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: lithium borohydride / diethyl ether / 19 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide; oil / 19 h / -10 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C

4: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

5: sodium methylate / methanol / 20 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 2 - 20 h / 15 - 20 °C

With lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; sulfur trioxide pyridine complex; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; oil;

Reference yield:

: 1147886-82-5
(R)-2-ethoxy-1-propanol

: 1160437-99-9
(3R,4R,5S)-4-[4-((R)-2-ethoxypropoxy-methyl)-phenyl]-3-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-(3-oxo-3-pyrrolidin-1-yl-propyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; oil / 19 h / -10 - 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C

3: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C

4: sodium methylate / methanol / 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 2 - 20 h / 15 - 20 °C

With tetrabutyl ammonium fluoride; hydrogen; sodium methylate; sulfur trioxide pyridine complex; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; oil;