(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

Base Information

Chemical Name:(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide
CAS No.:1443828-65-6
Molecular Formula:C₂₇H₃₁NO₅
Molecular Weight:449.547
Hs Code.:

Synonyms:(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

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Chemical Property of (R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

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Technology Process of (R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

There total 4 articles about (R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1443828-63-4
(R)-2-chloro-N-(3,4-dimethoxyphenylethyl)-N-(1-phenylethyl)acetamide

: 150-76-5
4-methoxy-phenol

: 1443828-65-6
(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

Guidance literature:: 4-methoxy-phenol; With caesium carbonate; In acetonitrile; at 20 ℃; for 1h;

(R)-2-chloro-N-(3,4-dimethoxyphenylethyl)-N-(1-phenylethyl)acetamide; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1021/jm400177t

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1443828-65-6
(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; water

2.1: boron trifluoride diethyl etherate; dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux

2.2: 1 h / 0 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: caesium carbonate / acetonitrile / 1 h / 20 °C

4.2: 16 h / 20 °C

With dimethylsulfide borane complex; boron trifluoride diethyl etherate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400177t

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 1443828-65-6
(R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane; water

2.1: boron trifluoride diethyl etherate; dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux

2.2: 1 h / 0 °C

3.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4.1: caesium carbonate / acetonitrile / 1 h / 20 °C

4.2: 16 h / 20 °C

With dimethylsulfide borane complex; boron trifluoride diethyl etherate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400177t