(1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester
• CAS No.: 959122-67-9
• Molecular Formula: C₂₈H₂₄F₄N₂O₄
• Molecular Weight: 528.503

Synonyms:(1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester

Chemical Property of (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester

There total 1 articles about (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (1R,2R)-2-[(4'-amino-1,1'-biphenyl-4-yl)carbonyl]cyclopentanecarboxylate (959123-13-8) + 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene (69922-27-6) → (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester (959122-67-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm7013887

Reference yield:

(1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid methyl ester (959122-67-9) → (1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid (959122-68-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/jm7013887

upstream raw materials:

methyl (1R,2R)-2-[(4'-amino-1,1'-biphenyl-4-yl)carbonyl]cyclopentanecarboxylate

1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene

Downstream raw materials:

(1R,2R)-2-({4'-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]-1,1'-biphenyl-4-yl}carbonyl)cyclopentanecarboxylic acid

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