3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

Base Information

Chemical Name:3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid
CAS No.:1073543-82-4
Molecular Formula:C₂₆H₂₅FO₄
Molecular Weight:420.481
Hs Code.:

Synonyms:3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

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Chemical Property of 3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

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Technology Process of 3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

There total 6 articles about 3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1073545-51-3
3-(chloromethyl)-6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

: 621-54-5
3-(3-hydroxyphenyl)-propanoic acid

: 1073543-82-4
3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

Guidance literature:: 3-(3-hydroxyphenyl)-propanoic acid; With tetra-n-butylphosphonium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.166667h;

3-(chloromethyl)-6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl; In tetrahydrofuran; water; at 0 - 20 ℃; for 44h;

Reference yield:

: 1073545-45-5
methyl 3-chloro-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-5-carboxylate

: 1073543-82-4
3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / 1,4-dioxane; water / 4.08 h / 20 - 88 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 19 h / 0 - 20 °C

4.1: tetra-n-butylphosphonium hydroxide / tetrahydrofuran; water / 0.17 h / 0 °C

4.2: 44 h / 0 - 20 °C

With potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; tetra-n-butylphosphonium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 107947-17-1
methyl 3-bromo-4-chlorobenzoate

: 1073543-82-4
3-(3-(((6-cyclopropyl-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 17 h / 100 °C

2.1: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / 1,4-dioxane; water / 4.08 h / 20 - 88 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 19 h / 0 - 20 °C

5.1: tetra-n-butylphosphonium hydroxide / tetrahydrofuran; water / 0.17 h / 0 °C

5.2: 44 h / 0 - 20 °C

With potassium phosphate; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; tetra-n-butylphosphonium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;