3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

Base Information

Chemical Name:3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester
CAS No.:1198181-69-9
Molecular Formula:C₁₆H₂₀F₃NO₂
Molecular Weight:315.336
Hs Code.:

Synonyms:3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

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Chemical Property of 3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

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Technology Process of 3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

There total 2 articles about 3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 276872-86-7
benzyl 3-formylpyrrolidine-1-carboxylate

: 1198181-69-9
3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 4 h

2.1: hydrogen / 20 % Pd(OH)2/C / methanol / 4 h / 40 °C

3.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.1 h / 120 °C / Inert atmosphere; Sealed container; Microwave irradiation

With hydrogen; sodium hydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 % Pd(OH)2/C; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;

Reference yield:

: C₁₇H₂₁NO₄

: 1198181-69-9
3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 20 % Pd(OH)2/C / methanol / 4 h / 40 °C

2: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.1 h / 120 °C / Inert atmosphere; Sealed container; Microwave irradiation

With hydrogen; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 % Pd(OH)2/C; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; 1,2-dimethoxyethane;

Reference yield:

: 1198181-69-9
3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester

: 1198180-29-8
3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid

Guidance literature:: 3-{1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl}propanoic acid ethyl ester; With lithium hydroxide monohydrate; sodium hydroxide; In ethanol; at 20 ℃; for 16h;

With hydrogenchloride; In ethanol; water;