tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

Base Information

Chemical Name:tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate
CAS No.:1377963-20-6
Molecular Formula:C₂₇H₃₃N₅O₅S₂
Molecular Weight:571.722
Hs Code.:

Synonyms:tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

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Chemical Property of tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

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Technology Process of tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

There total 7 articles about tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[4-(6-chloro-pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzenesulfonamide para-toluenesulfonate

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1377963-20-6
tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 96 ℃; for 6h;

Reference yield:

: 406233-31-6
4-fluoro-3-nitrobenzenesulfonamide

: 1377963-20-6
tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium / 2.5 h / Reflux

1.2: 20 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C

3.1: sodium hydrogencarbonate / chloroform; water / 1.5 h / 20 °C

4.1: ammonia / methanol / 18 h / 20 °C

5.1: ethanol / 48 h / 20 °C

6.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 6 h / 96 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; sodium; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; chloroform; water;

Reference yield:

: 90566-23-7
3-Amino-4-isopropoxy-benzenesulfonamide

: 1377963-20-6
tert-butyl 5-(2-((2-isopropoxy-5-sulfamoylphenyl)amino)thiazol-4-yl)-5',6'-dihydro-[2,4'-bipyridine]-1'(2'H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / chloroform; water / 1.5 h / 20 °C

2: ammonia / methanol / 18 h / 20 °C

3: ethanol / 48 h / 20 °C

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 6 h / 96 °C

With ammonia; sodium hydrogencarbonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; chloroform; water;