2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

Base Information

Chemical Name:2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone
CAS No.:1197342-20-3
Molecular Formula:C₂₁H₁₅BrCl₂N₄O
Molecular Weight:490.186
Hs Code.:

Synonyms:2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

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Chemical Property of 2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

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Technology Process of 2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

There total 4 articles about 2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197342-19-0
1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]-2-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

: 183438-24-6
5-bromo-2-iodopyrimidine

: 1197342-20-3
2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

Guidance literature:: With potassium phosphate tribasic trihydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1197342-17-8
3-chloro-1-(2,5-dichlorophenyl)propan-1-one

: 1197342-20-3
2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 18 h / 20 °C

2.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

3.1: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

With hydrazine hydrate; potassium phosphate tribasic trihydrate; potassium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 1197342-18-9
2-(3-bromophenyl)-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

: 1197342-20-3
2-[3-(5-bromopyrimidin-2-yl)phenyl]-1-[3-(2,5-dichlorophenyl)-4,5-dihydropyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

With potassium phosphate tribasic trihydrate; potassium acetate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;