(4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

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Chemical Name:(4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one
CAS No.:1532540-60-5
Molecular Formula:C₂₅H₃₆F₃NO₄Si
Molecular Weight:499.646
Hs Code.:

Synonyms:(4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

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Chemical Property of (4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

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Technology Process of (4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

There total 2 articles about (4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 1532540-58-1
(4S)-4-benzyl-3-{(2S,3R)-3-hydroxy-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

: 1532540-60-5
(4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere; Schlenk technique;
DOI:10.1055/s-0033-1339755

Reference yield:

: 1414349-03-3
(S)-4-benzyl-3-((R)-3-(trifluoromethyl)pentanoyl)oxazolidin-2-one

: 1532540-60-5
(4S)-4-benzyl-3-{(2S,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(2R)-1,1,1-trifluorobutan-2-yl]pent-4-enoyl}oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere; Schlenk technique

1.2: 13 h / -78 - 0 °C / Inert atmosphere; Schlenk technique

2.1: 2,6-dimethylpyridine / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With 2,6-dimethylpyridine; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1.1: |Aldol Addition / 1.2: |Aldol Addition;
DOI:10.1055/s-0033-1339755