1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Base Information

Chemical Name:1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid
CAS No.:133166-49-1
Molecular Formula:C₁₇H₁₁BrClFN₂O₄
Molecular Weight:441.641
Hs Code.:

Synonyms:1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

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Chemical Property of 1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

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Technology Process of 1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

There total 5 articles about 1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136147-06-3
ethyl 1-(4-bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetate

: 133166-49-1
1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: With hydrogenchloride; sulfuric acid; acetic acid; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield:

: [1-(4-Bromo-2-fluoro-benzyl)-6-chloro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-acetic acid methyl ester

: 133166-49-1
1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 0.5h;
DOI:10.1021/jm00108a038

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 133166-49-1
1-(4-Bromo-2-fluorophenyl)methyl-6-chloro-1,4-dihydro-2,4-dioxo-3(2H)-quinazolineacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH (80percent dispersion in mineral oil) / 1.) DMF, 2 h, 2.) 8 h

2: 83.9 percent / toluene / 6 h / 100 °C

3: toluene / 4 h / 90 °C

4: 2.5 N aq. NaOH / methanol; tetrahydrofuran / 0.5 h

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm00108a038