tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

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Chemical Name:tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate
CAS No.:1167416-09-2
Molecular Formula:C₂₇H₃₂ClN₃O₄
Molecular Weight:498.022
Hs Code.:

Synonyms:tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

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Chemical Property of tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

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Technology Process of tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

There total 9 articles about tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1167416-89-8
6-(5-{3-chloro-4-[(1-methyl ethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 1167416-09-2
tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h; Microwave irradiation;

Reference yield: 92.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1167415-51-1
6-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

: 1167416-09-2
tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h; Microwave irradiation;
DOI:10.1021/jm5010336

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1167416-09-2
tert-butyl 2-(6-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 1 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 100 °C / Microwave irradiation

With sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm5010336