4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Base Information

Chemical Name:4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine
CAS No.:1614245-70-3
Molecular Formula:C₂₂H₂₁FN₄O₃S
Molecular Weight:440.498
Hs Code.:

Synonyms:4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Suppliers and Price of 4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
PF-06372865 98.11%
100mg
$ 1350.00

ChemScene
PF-06372865 98.11%
50mg
$ 850.00

ChemScene
PF-06372865 98.11%
25mg
$ 550.00

ChemScene
PF-06372865 98.11%
5mg
$ 150.00

ChemScene
PF-06372865 98.11%
10mg
$ 250.00

Biosynth Carbosynth
PF 06372865
10 mg
$ 225.00

AK Scientific
CID76287260
10mg
$ 353.00

Total 2 raw suppliers

Chemical Property of 4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Chemical Property:

Melting Point:184 - 186°C

Purity/Quality:

97% ^*data from raw suppliers

PF-06372865 98.11% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses PF 06372865 are used as GABAA receptor modulators to treat pain.

Technology Process of 4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

There total 13 articles about 4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1614246-94-4
7-ethyl-4-[4-fluoro-3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]-7H-imidazo[4,5-c]pyridazine

: 1614246-34-2
1-bromo-4-(ethylsulfonyl)-2-methoxybenzene

: 1614245-70-3
4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 2h;
DOI:10.1021/acs.jmedchem.9b00322

Reference yield: 13.0%

: 1614246-27-3
7-ethyl-4-(4-fluoro-3-iodophenyl)-7H-imidazo[4,5-c]pyridazine

: 1614246-36-4
2-(4-(ethylsulfonyl)-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1614245-70-3
4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1614246-24-0
5-chloro-N³-ethylpyridazine-3,4-diamine

: 1614245-70-3
4-(4'-(ethylsulfonyl)-6-fluoro-2'-methoxybiphenyl-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 4 h / Inert atmosphere; Reflux

3: 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid / dichloromethane / 0.08 h / 20 °C / Cooling with ice

4: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid; sodium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; water;