ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

Base Information

Chemical Name:ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate
CAS No.:844446-54-4
Molecular Formula:C₁₈H₂₆O₃
Molecular Weight:290.403
Hs Code.:

Synonyms:ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

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Chemical Property of ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

Chemical Property:

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Technology Process of ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

There total 3 articles about ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 844446-55-5
ethyl 4-hydroxy-2-(2-methoxy-5-methylphenyl)-2-methylcyclopentanecarboxylate

: 844446-54-4
ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 1 h / 0 °C

2: 926 mg / Bu₃SnH; AIBN / toluene / 0.67 h / Heating

3: 65 percent / LDA / tetrahydrofuran / -90 - 0 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene; 2: Barton-McCombie reaction;
DOI:10.1002/ejoc.200400395

Reference yield:

: 844446-51-1
ethyl (1S,2S,4R)-4-acetoxy-2-(2-methoxy-5-methylphenyl)-2-methylcyclopentanecarboxylate

: 844446-54-4
ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Na₂CO₃ / methanol / 48 h / 20 °C

2: NaH / tetrahydrofuran / 1 h / 0 °C

3: 926 mg / Bu₃SnH; AIBN / toluene / 0.67 h / Heating

4: 65 percent / LDA / tetrahydrofuran / -90 - 0 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; sodium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene; 3: Barton-McCombie reaction;
DOI:10.1002/ejoc.200400395

Reference yield:

: 844446-57-7
(1S,2S,4R)-2-(2-Methoxy-5-methyl-phenyl)-2-methyl-4-methylsulfanylthiocarboxyoxy-cyclopentanecarboxylic acid ethyl ester

: 844446-54-4
ethyl (1R,2R)-2-(2-methoxy-5-methylphenyl)-1,2-dimethylcyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 926 mg / Bu₃SnH; AIBN / toluene / 0.67 h / Heating

2: 65 percent / LDA / tetrahydrofuran / -90 - 0 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; toluene; 1: Barton-McCombie reaction;
DOI:10.1002/ejoc.200400395